Susac�s Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of\r\nan HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load\r\nand several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and\r\nintravenous immunoglobulins alone did not control the disease, which improved after combined treatment with\r\nacyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are\r\nconsistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute\r\nin this case of SS.
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